> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > N-RAS AntibodyBrand |
Leading Biology | Catalog Number |
APR06824G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality N-RAS Antibody.
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Molecular Weight |
Predicted: 21 Observed: 20 KDa
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Cellular Localization |
Antigen Cellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Note=Shuttles between the plasma membrane and the Golgi apparatus
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Host |
Rabbit
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Species Reactivity |
Human, Mouse, Rat
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Target |
NRAS; N-RAS antibody is predicted to not cross-react with H-RAS
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Isotype |
IgG
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Symbol |
HRAS1
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GeneID |
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UniProt ID |
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Function |
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
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Summary |
N-RAS Antibody: Activating mutations and overexpression of classical Ras subfamily members (N-RAS, H-RAS, and K-RAS) have been widely investigated as key events in the development of human cancers. The N-RAS protein shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. N-RAS, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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