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AGR2 Antibody

Catalog # Availability Size / Price Inquiry
APR06808G 0.1 mg / $695

AGR2 Antibody

Brand

Leading Biology

Catalog Number

APR06808G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality AGR2 Antibody.

Molecular Weight

19 kDa

Cellular Localization

Antigen Cellular Localization: Secreted. Endoplasmic reticulum

Host

Rabbit

Species Reactivity

Human, Mouse

Target

AGR2; Two isoforms of AGR2 exists as a result of alternative splicing event.

Isotype

IgG

Symbol

AG2

GeneID

UniProt ID

Function

Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth.

Summary

AGR2 Antibody: AGR2 (anterior gradient protein 2) and AGR3 are members of the anterior gradient homolog family. They are secreted cytoplasmic proteins which are involved in metastasis induction and p53 tumour supressor inhibition. They may serve as molecular markers and potential therapeutic targets for hormone-responsive breast tumours. AGR2 is ubiquitously expressed with upregulated expression in prostate cancer, breast cancer, lung cancer, renal carcinomas and endometrial carcinomas. AGR2 expression is positively correlated with that of the estrogen receptor (ER) and is negatively correlated with that of the epidermal growth factor receptor (EGFR).

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, IF, E

Images

Western blot analysis of AGR2 in Hela cell lysate with AGR2 antibody at (A) 1 and (B) 2 μg/mL

Immunohistochemistry of AGR2 in human small intestine tissue with AGR2 antibody at 5 μg/ml.

Immunofluorescence of AGR2 in human small intestine tissue with AGR2 antibody at 20 μg/ml.

Specification

Quantity

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