> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > MOX1 AntibodyBrand |
Leading Biology | Catalog Number |
APR06677G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality MOX1 Antibody.
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Molecular Weight |
27997 Da
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Cellular Localization |
Antigen Cellular Localization:
Nucleus {ECO:0000250|UniProtKB:P32442}. Cytoplasm {ECO:0000250|UniProtKB:P32442}. Note=Localizes predominantly in the nucleus. {ECO:0000250|UniProtKB:P32442}
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Host |
Rabbit
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Species Reactivity |
Human, Mouse, Rat
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Target |
MEOX1;
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Isotype |
IgG
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Symbol |
MOX1
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GeneID |
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UniProt ID |
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Function |
Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.
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Summary |
MOX1 Antibody: MOX1, also known as MEOX1, is a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes that is first expressed during gastrulation in the early mesoderm and later in presomitic mesoderm, early somites, dermomyotome and sclerotome. Both MOX1 and the related protein MOX2 are required for proper gene expression in all somitic compartments. MOX1 is an upstream regulator of the transcription factors Bapx1, Tbx18, and Uncx and is thus part of a regulatory circuit that functions in the maintenance of rostrocaudal sclerotome polarity and axial skeleton formation.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IF, ICC, E
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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