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Bora Antibody

Catalog # Availability Size / Price Inquiry
APR06531G 0.1 mg / $695

Bora Antibody

Brand

Leading Biology

Catalog Number

APR06531G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Bora Antibody.

Molecular Weight

61203 Da

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Target

C13orf34;

Isotype

IgG

Symbol

C13orf34

GeneID

UniProt ID

Function

Required for the activation of AURKA at the onset of mitosis.

Summary

Bora Antibody: Bora (Protein aurora borealis) is a key activator of Aurora Related Protein Kinase A (ARK-1), which is a centrosome-associated serine/threonine kinase that regulates centrosome maturation, bipolar spindle assembly and chromosome segregation during mitosis. Bora is localized to the nucleus until mitosis is initiated, then translocates to the cytoplasm in a Cdc2 dependent manner. Activation of Cdc2 initiates the release of Bora into the cytoplasm where it can bind and activate ARK-1. PLK1 (polo-like kinase-1) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation by ARK-1. Bora and ARK-1 cooperatively activate PLK1 and control mitotic entry. Bora mutants result in multipolar spindles in mitosis identical to those observed when ARK-1 function is blocked. Thus, the ARK1-Bora-PLK1 regulatory circuit in mammalian cells elucidates a key mechanism in cell cycle regulation. At least three isoforms of Bora are known to exist.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, IF, E

Images

Western blot analysis of Bora in mouse brain tissue lysate with Bora antibody at (A) 1 and (B) 2 μg/mL.

Immunohistochemistry of Bora in mouse brain tissue with Bora antibody at 2.5 μg/mL.

Immunofluorescence of Bora in Mouse Brain cells with Bora antibody at 20 μg/mL.

Specification

Quantity

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