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ST2 Antibody

Catalog # Availability Size / Price Inquiry
APR06352G 0.1 mg / $695

ST2 Antibody

Brand

Leading Biology

Catalog Number

APR06352G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ST2 Antibody.

Molecular Weight

64801 Da

Cellular Localization

Antigen Cellular Localization: Cell membrane; Single-pass type I membrane protein

Host

Rabbit

Species Reactivity

Human, Mouse

Target

Il1rl1;

Isotype

IgG

Symbol

Ly84, St2, Ste2

GeneID

UniProt ID

Function

Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8 (By similarity). Possibly involved in helper T-cell function.

Summary

ST2 Antibody: ST2 is a member of a superfamily containing the interleukin-1 receptor and the Toll-like receptors (TLRs). The TLRs are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. ST2 was originally identified as a protein whose production was stimulated by various proliferation-inducing agents such as PDGF and FGF. More recently, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor (TLR) 4 signaling and to maintain endotoxin tolerance. It has been suggested that the inhibition of TLR4 signaling occurs through the association and sequestering of TLR adaptor molecules such as MyD88 and TIRAP.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, IF, E

Images

Western blot analysis of ST2 in 293 cell lysate with ST2 antibody at 1g/ml in (A) the absence and (B) the presence of blocking peptide.

Immunohistochemistry of ST2 in mouse kidney tissue with ST2 antibody at 2 μg/mL.

Immunofluorescence of ST2 in Mouse Kidney cells with ST2 antibody at 20 μg/mL.

Specification

Quantity

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