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PERP Antibody

Catalog # Availability Size / Price Inquiry
APR06288G 0.1 mg / $695

PERP Antibody

Brand

Leading Biology

Catalog Number

APR06288G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PERP Antibody.

Molecular Weight

Predicted: 27 kDa Observed: 30 kDa

Cellular Localization

Antigen Cellular Localization: Cell junction, desmosome. Cell membrane; Multi-pass membrane protein. Note=Associated with desmosomes

Host

Rabbit

Species Reactivity

Human

Target

Perp;

Isotype

IgG

Symbol

Krtcap1

GeneID

UniProt ID

Function

Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway.

Summary

PERP Antibody: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2, MTBP and PERP, were identified and their genes were cloned recently. PERP, also termed PIGPC1 and THW, is a plasma membrane protein. p53 binds to the promoter of PERP and transcriptionally activates PERP gene then the translated PERP protein mediates the p53 induced apoptosis. The expression of PERP causes cell death. PERP is a mediator of p53 induced apoptosis. PERP has sequence similarity to PMP-22/gas3 and is a new member of the PMP-22/gas3 family.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, ICC, E

Images

Western blot analysis of PERP expression in A431 whole cell lysates in the absence (A) and presence (B) of blocking peptide with PERP antibody at 1 μg/mL.

Immunocytochemistry of PERP in A431 cells with PERP antibody at 10 μg/mL.

Specification

Quantity

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