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SnoN Antibody

Catalog # Availability Size / Price Inquiry
APR06264G 0.1 mg / $695

SnoN Antibody

Brand

Leading Biology

Catalog Number

APR06264G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SnoN Antibody.

Molecular Weight

76976 Da

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Target

SKIL;

Isotype

IgG

Symbol

SNO

GeneID

UniProt ID

Function

May have regulatory role in cell division or differentiation in response to extracellular signals.

Summary

SnoN Antibody: TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Like Ski, SnoN functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. SnoN is located primarily in the nucleus in cancer tissues or cells, but in the cytoplasm in normal tissues or primary epithelial cells. There are at least four alternately spliced isoforms of SnoN; SnoN antibody will recognize all isoforms (SnoN, SnoN2, SnoI, and SnoA).

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, IF, E

Images

Western blot analysis of SnoN in A431 cell lysate with SnoN antibody at (A) 0.5 and (B) 1 μg/mL.

Immunohistochemistry of SnoN in mouse lung tissue with SnoN antibody at 5 μg/mL.

Immunofluorescence of SnoN in Mouse Lung cells with SnoN antibody at 20 μg/mL.

Specification

Quantity

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