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FBXO7 antibody - middle region

Catalog # Availability Size / Price Inquiry
APR00880G 50 μg / $545

FBXO7 antibody - middle region

Brand

Leading Biology

Catalog Number

APR00880G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality FBXO7 antibody - middle region.

Molecular Weight

58kDa

Cellular Localization

Antigen Cellular Localization: Cytoplasm. Nucleus. Mitochondrion. Cytoplasm, cytosol. Note=Predominantly cytoplasmic. A minor proportion is detected in the nucleus. Relocates from the cytosol to depolarized mitochondria

Host

Rabbit

Species Reactivity

Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Horse, Bovine, Guinea Pig, Dog

Symbol

FBX7

GeneID

UniProt ID

Function

Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PARK2 to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination.

Form

Liquid

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IP

Images

Immunoprecipitation -- 5ug antibody

WB Suggested Anti-FBXO7 Antibody Titration: 0.2-1 μg/ml ELISA Titer: 1:1562500 Positive Control: MCF7 cell lysateFBXO7 is supported by BioGPS gene expression data to be expressed in MCF7

FBXO7 antibody - middle region validated by WB using U2OS cells at 0.5μg/ml.

Specification

Quantity

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