> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > Phospho-Ser459 Protein Tyrosine Phosphatase H1 AntibodyBrand |
Leading Biology | Catalog Number |
APR03402G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Phospho-Ser459 Protein Tyrosine Phosphatase H1 Antibody.
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Molecular Weight |
104 KDa
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Host |
Rabbit
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Species Reactivity |
Human, Mouse
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Target |
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser459 conjugated to KLH.
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GeneID |
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UniProt ID |
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Summary |
Protein-tyrosine Phosphatase H1 (PTPH1) has recently been identified as a specific p38γMAPK phosphatase which is mediated through PDZ interaction (Hou et al., 2010). Ras has beendemonstrated to increase both p38γand PTPH1 protein expression, and there is a coupling of increasedp38γand PTPH1 protein expression in primary colon cancer tissues (Hou et al., 2010). Phosphorylation ofPTPH1 at Ser459 leads to PTPH1 stabilization, which plays an important role in Ras oncogenesis and stressresponse (Hou et al., 2012). Additionally, phosphorylation of PTPH1 Ser459 reveals a novel mechanism bywhich MAPK signals through PTPH1 to regulate cellular response (Hou et al., 2012).
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB
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Dilution |
WB~~ 1:1000
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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