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Location: Home > Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > SNAI1 / SNAIL-1 Antibody (Internal)

SNAI1 / SNAIL-1 Antibody (Internal)

Catalog # Availability Size / Price Inquiry
APR03360G 50 μl / $495

SNAI1 / SNAIL-1 Antibody (Internal)

Brand

Leading Biology

Catalog Number

APR03360G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SNAI1 / SNAIL-1 Antibody (Internal).

Molecular Weight

29083 Da

Cellular Localization

Antigen Cellular Localization: Nucleus. Cytoplasm. Note=Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs

Host

Rabbit

Species Reactivity

Human

Target

Human SNAI1 / SNAIL-1.

Isotype

IgG

Symbol

SNAH

GeneID

UniProt ID

Function

Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up- regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.

Summary

Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up- regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, IF, ICC

Dilution

ICC (1:100 - 1:1000), IF (1:100 - 1:1000), IHC-P (10 μg/ml),

Images

Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)

Confocal immunofluorescence analysis of paraformaldehyde-fixed HeLa, using SNAI1 antibody...

Specification

Quantity

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