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Monoclonal Antibodies >
CD74 Antibody (clone PIN.1)Brand |
Leading Biology | Catalog Number |
AMM02170G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CD74 Antibody (clone PIN.1).
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Molecular Weight |
34kDa
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Cellular Localization |
Antigen Cellular Localization:
Cell membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome Lysosome. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane
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Host |
Mouse
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Species Reactivity |
Human
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Target |
Detects ~33-35 kD protein doublet, corresponding to the molecular mass of the p33 and p35 forms of human CD74 on SDS-PAGE immunoblots.
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Clone |
PIN.1
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Symbol |
DHLAG
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GeneID |
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UniProt ID |
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Function |
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
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Summary |
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, IP, Flo
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Dilution |
IHC-P (10 μg/ml), WB (1 μg/ml),
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Images |
CD-74 (PIN 1.1) N87 lysates mixed with macrophage inhibitory factor. |
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Specification |
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Quantity |
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