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TANK Antibody (C-Terminus)

Catalog # Availability Size / Price Inquiry
APR02277G 50 μg / $495

TANK Antibody (C-Terminus)

Brand

Leading Biology

Catalog Number

APR02277G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TANK Antibody (C-Terminus).

Molecular Weight

48kDa

Cellular Localization

Antigen Cellular Localization: Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Target

14 amino acid peptide from near the carboxy terminus of human TANK

Symbol

ITRAF, TRAF2

GeneID

UniProt ID

Function

Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.

Summary

Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.

Form

Liquid

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, IF

Dilution

IHC-P (5 μg/ml)

Images

Immunofluorescence of TANK in Rat Spleen cells with TANK antibody at 20 ug/ml.

Western blot of TANK in Daudi cell lysate with TANK antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.

Anti-TANK antibody IHC of human kidney.

Specification

Quantity

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