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Location: Home > Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > A2M / Alpha-2-Macroglobulin Antibody

A2M / Alpha-2-Macroglobulin Antibody

Catalog # Availability Size / Price Inquiry
APG00995G 50 μl / $495

A2M / Alpha-2-Macroglobulin Antibody

Brand

Leading Biology

Catalog Number

APG00995G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality A2M / Alpha-2-Macroglobulin Antibody.

Molecular Weight

163kDa

Cellular Localization

Antigen Cellular Localization: Secreted.

Host

Goat

Species Reactivity

Human

Target

A2-Macroglobulin [Human Plasma].

Symbol

CPAMD5

GeneID

UniProt ID

Function

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Summary

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Form

Liquid

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, E, IP

Dilution

ELISA (1:80000-1:400000), IHC-P (2.5 μg/ml), WB (1:2000-1:20000)

Images

Anti-A2M / Alpha-2-Macroglobulin antibody IHC of human liver.

Specification

Quantity

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