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Polyclonal Antibodies >
CDK12 / CRKRS Antibody (C-Terminus)Brand |
Leading Biology | Catalog Number |
APR02059G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CDK12 / CRKRS Antibody (C-Terminus).
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Molecular Weight |
164kDa
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Cellular Localization |
Antigen Cellular Localization:
Nucleus. Nucleus speckle. Note=Colocalized with nuclear speckles throughout interphase
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Host |
Rabbit
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Species Reactivity |
Human, Mouse, Rabbit, Hamster, Monkey, Dog
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Target |
Human CDK12 / CRKRS. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except POMT1 (37%).
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Symbol |
CRK7, CRKRS, KIAA0904
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GeneID |
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UniProt ID |
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Function |
Cyclin-dependent kinase that phosphorylates the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
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Summary |
Cyclin-dependent kinase that phosphorylates the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
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Form |
Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
IHC-P
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Dilution |
IHC-P (4-5 μg/ml)
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Images |
Anti-CDK12 / CRKRS antibody IHC of human Skin, Melanoma. Anti-CDK12 / CRKRS antibody APR02059G IHC of human spleen. |
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Specification |
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Quantity |
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