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Location: Home > Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > Goat Anti-CCAR2 / DBC1 Antibody (internal region)

Goat Anti-CCAR2 / DBC1 Antibody (internal region)

Catalog # Availability Size / Price Inquiry
APG00966G 100 μg / $495

Goat Anti-CCAR2 / DBC1 Antibody (internal region)

Brand

Leading Biology

Catalog Number

APG00966G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Goat Anti-CCAR2 / DBC1 Antibody (internal region).

Molecular Weight

102902 Da

Cellular Localization

Antigen Cellular Localization: Nucleus. Note=Recruited to chromatin, post-UV irradiation

Host

Goat

Species Reactivity

Human

Symbol

DBC1, KIAA1967

GeneID

UniProt ID

Function

Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3- specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation.

Form

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, E

Images

APG00966G (0.5 μg/ml) staining of HEK293 (A) and MCF7 (B) nuclear lysates (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Specification

Quantity

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