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NALP2 / NLRP Antibody (C-Term)

Catalog # Availability Size / Price Inquiry
APG00653G 0.1mg / $495

NALP2 / NLRP Antibody (C-Term)

Brand

Leading Biology

Catalog Number

APG00653G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality NALP2 / NLRP Antibody (C-Term).

Molecular Weight

120515 Da

Cellular Localization

Antigen Cellular Localization: Cytoplasm

Host

Goat

Species Reactivity

Human

Isotype

IgG

Symbol

NALP2, NBS1, PAN1, PYPAF2

GeneID

UniProt ID

Function

Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.

Form

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, E

Images

HEK293 lysate (10ug protein in RIPA buffer) overexpressing Human NLRP2 with DYKDDDDK tag probed with APG00653G (1ug/ml) in Lane A and probed with anti- DYKDDDDK Tag (1/1000) in lane C. Mock-transfected HEK293 probed with APG00653G (1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence.

Specification

Quantity

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