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CK17 Antibody

Catalog # Availability Size / Price Inquiry
AMM02723G 100 μl / $495

CK17 Antibody

Brand

Leading Biology

Catalog Number

AMM02723G

Product Type

Monoclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CK17 Antibody.

Molecular Weight

49kDa

Cellular Localization

Antigen Cellular Localization: Cytoplasm {ECO:0000250|UniProtKB:Q9QWL7}.

Host

Mouse

Species Reactivity

Human

Clone

3B12

Isotype

IgG2b

GeneID

UniProt ID

Function

Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC, E

Dilution

WB~~1/500 - 1/2000 IHC~~1/200 - 1/1000 FC~~1:200~~400 IF~~1:200~1000.

Images

Figure 1: Western blot analysis using CK17 mouse mAb against Hela (1), MCF-7 (2) and A431 (3) cell lysate.

Figure 2: Immunohistochemical analysis of paraffin-embedded human lung cancer (A), endometrial carcinoma (B), sublingual gland (C) and esophagus (D) tissues using CK17 mouse mAb with DAB staining.

Figure 4: Flow cytometric analysis of Hela cells using WNT1 mouse mAb (green) and negative control (purple).

Specification

Quantity

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