> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > EphA8 AntibodyBrand |
Leading Biology | Catalog Number |
AMM02684G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality EphA8 Antibody.
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Molecular Weight |
111003 Da
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Cellular Localization |
Antigen Cellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell projection. Early endosome membrane Note=Undergoes clathrin-mediated endocytosis upon EFNA5-binding and is targeted to early endosomes.
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Host |
Mouse
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Species Reactivity |
Human
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Clone |
9A12D8
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Isotype |
IgG1
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Symbol |
EEK, HEK3, KIAA1459
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GeneID |
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UniProt ID |
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Function |
Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity).
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1/500 - 1/2000
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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