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Location: Home > Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > Major Vault Protein (MVP) Antibody

Major Vault Protein (MVP) Antibody

Catalog # Availability Size / Price Inquiry
AMM01651G 7 ml / $495

Major Vault Protein (MVP) Antibody

Brand

Leading Biology

Catalog Number

AMM01651G

Product Type

Monoclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Major Vault Protein (MVP) Antibody.

Molecular Weight

104-110kDa

Cellular Localization

Antigen Cellular Localization: Cytoplasm. Nucleus, nuclear pore complex. Note=5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment

Host

Mouse

Species Reactivity

Human

Clone

1032

Isotype

Mouse / IgG1, kappa

Symbol

LRP

GeneID

UniProt ID

Function

Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

Summary

Recognizes a protein of 104kDa-110kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.

Form

Liquid

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

IHC, IF, FC

Images

Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with MVP Monoclonal Antibody (1032).

Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with MVP Monoclonal Antibody (1032).

Specification

Quantity

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