> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > Beta-2 Microglobulin (Renal Failure & Tumor Marker) AntibodyBrand |
Leading Biology | Catalog Number |
AMM01218G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Beta-2 Microglobulin (Renal Failure & Tumor Marker) Antibody.
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Molecular Weight |
12kDa
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Cellular Localization |
Antigen Cellular Localization:
Secreted. Note=Detected in serum and urine
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Host |
Mouse
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Species Reactivity |
Human
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Clone |
B2M/1118
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Isotype |
Mouse / IgG1, kappa
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GeneID |
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UniProt ID |
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Function |
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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Summary |
β2 microglobulin is a 12KDa protein with a pI of 5.6. Serum β2 microglobulin levels are a reflection of cell turnover. Levels rise with fever, inflammation, and infection. Increased serum levels are also seen in B-cell malignancies and in renal failure and may indicate a worse prognosis for patients with early-stage Hodgkin's lymphoma. In urine, increased levels are seen in proximal renal tubular disease as well as renal transplant rejection. β2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumours and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy).
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Form |
Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
IHC, IF, FC
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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