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SERPINC1 Antibody (C-term)

APR05795G Product Datasheet Protocol

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APR05795G		100 μl / $495

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Leading Biology Inc.

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SERPINC1 Antibody (C-term)

Brand	Leading Biology	Catalog Number	APR05795G
Product Type	Polyclonal Antibodies	Field of Research
Product Overview	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SERPINC1 Antibody (C-term).
Molecular Weight	52602 Da
Cellular Localization	Antigen Cellular Localization: Secreted, extracellular space.
Host	Rabbit
Species Reactivity	Human, Mouse
Immunogen	364-393 aa
Target	This SERPINC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 364-393 amino acids from the C-terminal region of human SERPINC1.
Isotype	Rabbit Ig
Symbol	AT3
GeneID	462
UniProt ID	P01008
Function	Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.
Summary	SERPINC1 is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin.
Storage & Stability	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Applications	WB, IHC-P, FC, IF, E
Dilution	WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 IF~~1:10~50
Images	Western blot analysis of lysate from human blood plasma tissue lysate, using SERPINC1 Antibody (C-term)(APR05795G). APR05795G was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane. Western blot analysis of SERPINC1 Antibody (C-term) (Cat. APR05795G) in mouse liver tissue lysates (35ug/lane). SERPINC1 (arrow) was detected using the purified Pab. Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with SERPINC1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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