> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > OASL Antibody (C-term)Brand |
Leading Biology | Catalog Number |
APR05723G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality OASL Antibody (C-term).
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Molecular Weight |
59226 Da
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Cellular Localization |
Antigen Cellular Localization:
Isoform p56: Nucleus, nucleolus. Cytoplasm.
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
484-514 aa
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Target |
This OASL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 484-514 amino acids from the C-terminal region of human OASL.
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Isotype |
Rabbit Ig
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Symbol |
TRIP14
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GeneID |
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UniProt ID |
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Function |
Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.
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Summary |
2-prime,5-prime oligoadenylates (2-5As) bind to and activate RNase L, leading to degradation of RNA and inhibition of protein synthesis. 2-5As are produced by 2-5A synthetases (OASs), a highly-conserved family of interferon-induced enzymes. The predicted 514-amino acid human p59OASL (2-5A synthetases-like) protein shares a highly conserved N-terminal domain with other OASs. The C-terminal portion of p59OASL contains 2 ubiquitin-like domains. p59OASL is expressed in most tissues, with the highest levels in hematopoietic tissues, colon, and stomach.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, E
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Dilution |
WB~~1:1000
IHC-P~~1:50~100
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Images |
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Specification |
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Quantity |
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| 5 | Leading Biology | APR04349G | HECTD2 Antibody (N-term) | 100 μl | Polyclonal Antibodies |
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| 6 | Leading Biology | APR03502G | IGHG1 Antibody (Center) | 100 μl | Polyclonal Antibodies |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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