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TGIF2 Antibody (C-term)

Catalog # Availability Size / Price Inquiry
APR04017G 100 μl / $495

TGIF2 Antibody (C-term)

Brand

Leading Biology

Catalog Number

APR04017G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TGIF2 Antibody (C-term).

Molecular Weight

25878 Da

Cellular Localization

Antigen Cellular Localization: Nucleus. Note=Excluded from nucleoli.

Host

Rabbit

Species Reactivity

Human

Immunogen

171-199 aa

Target

This TGIF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 171-199 amino acids from the C-terminal region of human TGIF2.

Isotype

Rabbit Ig

GeneID

UniProt ID

Function

Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.

Summary

The protein encoded by this gene is a DNA-binding homeoboxprotein and a transcriptional repressor. The encoded proteinappears to repress transcription by recruiting histone deacetylasesto TGF beta-responsive genes. This gene is amplified andoverexpressed in some ovarian cancers, and mutations in this genecan cause holoprosencephaly.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, FC, E

Dilution

WB~~1:1000 FC~~1:10~50

Images

Anti-TGIF2 Antibody (C-term) at 1:1000 dilution + 293 whole cell lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 26 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

TGIF2 Antibody (C-term) (Cat. APR04017G) flow cytometric analysis of Neuro-2a cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.

Specification

Quantity

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