> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > ZP4 Antibody (C-term)Brand |
Leading Biology | Catalog Number |
APR03731G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ZP4 Antibody (C-term).
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Molecular Weight |
59400 Da
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Cellular Localization |
Antigen Cellular Localization:
Processed zona pellucida sperm-binding protein 4: Secreted, extracellular space, extracellular matrix Note=The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian oocyte is called zona pellucida
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
445-474 aa
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Target |
This ZP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 445-474 amino acids from the C-terminal region of human ZP4.
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Isotype |
Rabbit Ig
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Symbol |
ZPB
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GeneID |
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UniProt ID |
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Function |
The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.
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Summary |
The zona pellucida is an extracellular matrix thatsurrounds the oocyte and early embryo. It is composed primarily ofthree or four glycoproteins with various functions duringfertilization and preimplantation development. The nascent proteincontains a N-terminal signal peptide sequence, a conserved ZPdomain, a consensus furin cleavage site, and a C-terminaltransmembrane domain. It is hypothesized that furin cleavageresults in release of the mature protein from the plasma membranefor subsequent incorporation into the zona pellucida matrix.However, the requirement for furin cleavage in this process remainscontroversial based on mouse studies. Previously, this gene hasbeen referred to as ZP1 or ZPB and thought to have similarfunctions as mouse Zp1. However, a human gene with highersimilarity and chromosomal synteny to mouse Zp1 has been assignedthe symbol ZP1 and this gene has been assigned the symbol ZP4.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, E
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Dilution |
WB~~1:1000
IHC-P~~1:10~50
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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