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INSC Antibody (Center)

Catalog # Availability Size / Price Inquiry
APR06185G 100 μl / $495

INSC Antibody (Center)

Brand

Leading Biology

Catalog Number

APR06185G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality INSC Antibody (Center).

Molecular Weight

63469 Da

Cellular Localization

Antigen Cellular Localization: Cytoplasm. Note=Localizes to the apical cortex of mitotic epidermal cells and to the apical side of neuronal progenitor cells.

Host

Rabbit

Species Reactivity

Human

Immunogen

410-437 aa

Target

This INSC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 410-437 amino acids from the Central region of human INSC.

Isotype

Rabbit Ig

GeneID

UniProt ID

Function

May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis it may regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium.

Summary

In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, E

Dilution

WB~~1:1000 IHC-P~~1:50~100

Images

Western blot analysis of INSC Antibody (Center) (Cat. APR06185G) in WiDr cell line lysates (35ug/lane). INSC (arrow) was detected using the purified Pab.

INSC Antibody (Center) (Cat. APR06185G) IHC analysis in formalin fixed and paraffin embedded hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the INSC Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

Specification

Quantity

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