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TNFRSF10D Antibody (Center)

Catalog # Availability Size / Price Inquiry
APR06175G 100 μl / $495

TNFRSF10D Antibody (Center)

Brand

Leading Biology

Catalog Number

APR06175G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TNFRSF10D Antibody (Center).

Molecular Weight

41823 Da

Cellular Localization

Antigen Cellular Localization: Membrane; Single-pass type I membrane protein

Host

Rabbit

Species Reactivity

Human

Immunogen

252-278 aa

Target

This TNFRSF10D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 252-278 amino acids from the Central region of human TNFRSF10D.

Isotype

Rabbit Ig

Symbol

DCR2, TRAILR4, TRUNDD

GeneID

UniProt ID

Function

Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF- kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.

Summary

TNFRSF is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, FC, E

Dilution

WB~~1:1000 FC~~1:10~50

Images

Western blot analysis of TNFRSF10D Antibody (Center) (Cat. APR06175G) in HL-60 cell line lysates (35ug/lane). TNFRSF10D (arrow) was detected using the purified Pab.

TNFRSF10D Antibody (Center) (Cat. APR06175G) flow cytometry analysis of Hela cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Specification

Quantity

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