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F13B Antibody (N-term)

Catalog # Availability Size / Price Inquiry
APR04523G 100 μl / $495

F13B Antibody (N-term)

Brand

Leading Biology

Catalog Number

APR04523G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality F13B Antibody (N-term).

Molecular Weight

75511 Da

Cellular Localization

Antigen Cellular Localization: Secreted.

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

151-179 aa

Target

This F13B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-179 amino acids from the N-terminal region of human F13B.

Isotype

Rabbit Ig

GeneID

UniProt ID

Function

The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.

Summary

This gene encodes coagulation factor XIII B subunit.Coagulation factor XIII is the last zymogen to become activated inthe blood coagulation cascade. Plasma factor XIII is aheterotetramer composed of 2 A subunits and 2 B subunits. The Asubunits have catalytic function, and the B subunits do not haveenzymatic activity and may serve as a plasma carrier molecules.Platelet factor XIII is comprised only of 2 A subunits, which areidentical to those of plasma origin. Upon activation by thecleavage of the activation peptide by thrombin and in the presenceof calcium ion, the plasma factor XIII dissociates its B subunitsand yields the same active enzyme, factor XIIIa, as platelet factorXIII. This enzyme acts as a transglutaminase to catalyze theformation of gamma-glutamyl-epsilon-lysine crosslinking betweenfibrin molecules, thus stabilizing the fibrin clot. Factor XIIIdeficiency is classified into two categories: type I deficiency,characterized by the lack of both the A and B subunits; and type IIdeficiency, characterized by the lack of the A subunit alone.These defects can result in a lifelong bleeding tendency, defectivewound healing, and habitual abortion.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, E

Dilution

WB~~1:1000

Images

Anti-F13B Antibody (N-term) at 1:1000 dilution + human liver lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 76 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

F13B Antibody (N-term) (Cat. APR04523G) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the F13B antibody detected the F13B protein (arrow).

Specification

Quantity

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