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IL28RA Antibody (C-term)

Catalog # Availability Size / Price Inquiry
APR04518G 100 μl / $495

IL28RA Antibody (C-term)

Brand

Leading Biology

Catalog Number

APR04518G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality IL28RA Antibody (C-term).

Molecular Weight

57653 Da

Cellular Localization

Antigen Cellular Localization: Membrane; Single-pass type I membrane protein

Host

Rabbit

Species Reactivity

Human

Immunogen

485-513 aa

Target

This IL28RA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 485-513 amino acids from the C-terminal region of human IL28RA.

Isotype

Rabbit Ig

Symbol

IL28RA, LICR2

GeneID

UniProt ID

Function

The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.

Summary

The protein encoded by this gene belongs to the class IIcytokine receptor family. This protein forms a receptor complexwith interleukine 10 receptor, beta (IL10RB). The receptor complexhas been shown to interact with three closely related cytokines,including interleukin 28A (IL28A), interleukin 28B (IL28B), andinterleukin 29 (IL29). The expression of all three cytokines can beinduced by viral infection. The cells overexpressing this proteinhave been found to have enhanced responses to IL28A and IL29, butdecreased response to IL28B. Three alternatively spliced transcriptvariants encoding distinct isoforms have been reported. [providedby RefSeq].

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, E

Dilution

WB~~1:1000

Images

IL28RA Antibody (C-term) (Cat. APR04518G) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the IL28RA antibody detected the IL28RA protein (arrow).

Specification

Quantity

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