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TAPBP Antibody (N-term)

Catalog # Availability Size / Price Inquiry
APR04344G 100 μl / $495

TAPBP Antibody (N-term)

Brand

Leading Biology

Catalog Number

APR04344G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TAPBP Antibody (N-term).

Molecular Weight

47626 Da

Cellular Localization

Antigen Cellular Localization: Endoplasmic reticulum membrane; Single-pass type I membrane protein

Host

Rabbit

Species Reactivity

Human

Immunogen

42-70 aa

Target

This TAPBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-70 amino acids from the N-terminal region of human TAPBP.

Isotype

Rabbit Ig

Symbol

NGS17, TAPA

GeneID

UniProt ID

Function

Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).

Summary

This gene encodes a transmembrane glycoprotein whichmediates interaction between newly assembled majorhistocompatibility complex (MHC) class I molecules and thetransporter associated with antigen processing (TAP), which isrequired for the transport of antigenic peptides across theendoplasmic reticulum membrane. This interaction is essential foroptimal peptide loading on the MHC class I molecule. Up to fourcomplexes of MHC class I and this protein may be bound to a singleTAP molecule. This protein contains a C-terminal double-lysinemotif (KKKAE) known to maintain membrane proteins in theendoplasmic reticulum. This gene lies within the majorhistocompatibility complex on chromosome 6. Alternative splicingresults in three transcript variants encoding different isoforms.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, E

Dilution

WB~~1:1000

Images

TAPBP Antibody (N-term) (Cat. APR04344G) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the TAPBP antibody detected the TAPBP protein (arrow).

Specification

Quantity

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