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USP1 Antibody (C-term)

Catalog # Availability Size / Price Inquiry
APR04151G 100 μl / $495

USP1 Antibody (C-term)

Brand

Leading Biology

Catalog Number

APR04151G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality USP1 Antibody (C-term).

Molecular Weight

88207 Da

Cellular Localization

Antigen Cellular Localization: Nucleus.

Host

Rabbit

Species Reactivity

Human

Immunogen

662-690 aa

Target

This USP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 662-690 amino acids from the C-terminal region of human USP1.

Isotype

Rabbit Ig

GeneID

UniProt ID

Function

Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity.

Summary

This gene encodes a member of the ubiquitin-specificprocessing (UBP) family of proteases that is a deubiquitinatingenzyme (DUB) with His and Cys domains. This protein is located inthe cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fusedprecursors and ubiquitinylated proteins. The protein specificallydeubiquitinates a protein in the Fanconi anemia (FA) DNA repairpathway. Alternate transcriptional splice variants have beencharacterized.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, E

Dilution

WB~~1:1000

Images

USP1 Antibody (C-term) (Cat. APR04151G) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the USP1 antibody detected the USP1 protein (arrow).

Specification

Quantity

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