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MAS1 Antibody (C-term)

Catalog # Availability Size / Price Inquiry
APR03929G 100 μl / $495

MAS1 Antibody (C-term)

Brand

Leading Biology

Catalog Number

APR03929G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MAS1 Antibody (C-term).

Molecular Weight

37465 Da

Cellular Localization

Antigen Cellular Localization: Cell membrane; Multi-pass membrane protein

Host

Rabbit

Species Reactivity

Human

Immunogen

285-314 aa

Target

This MAS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 285-314 amino acids from the C-terminal region of human MAS1.

Isotype

Rabbit Ig

Symbol

MAS

GeneID

UniProt ID

Function

Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.

Summary

The structure of the MAS1 product indicates that itbelongs to the class of receptors that are coupled to GTP-bindingproteins and share a conserved structural motif, which is describedas a '7-transmembrane segment' following the prediction that thesehydrophobic segments form membrane-spanning alpha-helices. The MAS1protein may be a receptor that, when activated, modulates acritical component in a growth-regulating pathway to bring aboutoncogenic effects.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, E

Dilution

WB~~1:1000

Images

MAS1 Antibody (C-term) (Cat. APR03929G) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the MAS1 antibody detected the MAS1 protein (arrow).

Specification

Quantity

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