> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > RHOC Antibody (C-term)Brand |
Leading Biology | Catalog Number |
APR03908G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality RHOC Antibody (C-term).
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Molecular Weight |
22006 Da
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Cellular Localization |
Antigen Cellular Localization:
Cell membrane; Lipid-anchor; Cytoplasmic side. Cleavage furrow. Note=Translocates to the equatorial region before furrow formation in a ECT2-dependent manner
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Host |
Rabbit
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Species Reactivity |
Human, Mouse
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Immunogen |
102-130 aa
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Target |
This RHOC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-130 amino acids from the C-terminal region of human RHOC.
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Isotype |
Rabbit Ig
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Symbol |
ARH9, ARHC
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GeneID |
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UniProt ID |
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Function |
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.
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Summary |
This gene encodes a member of the Rho family of smallGTPases, which cycle between inactive GDP-bound and activeGTP-bound states and function as molecular switches in signaltransduction cascades. Rho proteins promote reorganization of theactin cytoskeleton and regulate cell shape, attachment, andmotility. The protein encoded by this gene is prenylated at itsC-terminus, and localizes to the cytoplasm and plasma membrane. Itis thought to be important in cell locomotion. Overexpression ofthis gene is associated with tumor cell proliferation andmetastasis. Multiple alternatively spliced variants, encoding thesame protein, have been identified.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:2000
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Images |
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Specification |
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Quantity |
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| 6 | Leading Biology | APR03502G | IGHG1 Antibody (Center) | 100 μl | Polyclonal Antibodies |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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