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MARCH11 Antibody (C-term)

Catalog # Availability Size / Price Inquiry
APR03870G 100 μl / $495

MARCH11 Antibody (C-term)

Brand

Leading Biology

Catalog Number

APR03870G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MARCH11 Antibody (C-term).

Molecular Weight

43878 Da

Cellular Localization

Antigen Cellular Localization: Cytoplasmic vesicle membrane; Multi-pass membrane protein

Host

Rabbit

Species Reactivity

Human

Immunogen

308-337 aa

Target

This MARCH11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-337 amino acids from the C-terminal region of human MARCH11.

Isotype

Rabbit Ig

GeneID

UniProt ID

Function

E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids (By similarity).

Summary

MARCH11 is a member of the MARCH family of membrane-boundE3 ubiquitin ligases (EC 6.3.2.19). These enzymes add ubiquitin(see MIM 191339) to target lysines in substrate proteins, therebysignaling their intracellular transport. March11 appears to have arole in ubiquitin-mediated protein sorting in the trans-Golginetwork (TGN)-multivesicular body (MVB) transport pathway (Morokumaet al., 2007 [PubMed 17604280]).

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, E

Dilution

WB~~1:1000

Images

MARCH11 Antibody (C-term) (Cat. APR03870G) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the 40613 antibody detected the 40613 protein (arrow).

Specification

Quantity

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