> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > REC8 Antibody (Center)Brand |
Leading Biology | Catalog Number |
APR03837G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality REC8 Antibody (Center).
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Molecular Weight |
62614 Da
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Cellular Localization |
Antigen Cellular Localization:
Nucleus. Chromosome. Note=In meiotic chromosomes, localized along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and metaphase I, localized along interstitial axes of chromosomes including both centromere and arm regions. No longer detected in arm regions in anaphase I but persists on centromere regions until metaphase II (By similarity) Localised to centromeres and spindle poles in endopolyploid tumor cells.
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
194-222 aa
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Target |
This REC8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 194-222 amino acids from the Central region of human REC8.
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Isotype |
Rabbit Ig
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Symbol |
REC8L1
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GeneID |
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UniProt ID |
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Function |
Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity).
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Summary |
This gene encodes a member of the kleisin family of SMC(structural maintenance of chromosome) protein partners. Theprotein localizes to the axial elements of chromosomes duringmeiosis in both oocytes and spermatocytes. In the mouse, thehomologous protein is a key component of the meiotic cohesioncomplex, which regulates sister chromatid cohesion andrecombination between homologous chromosomes. Multiplealternatively spliced variants, encoding the same protein, havebeen found for this gene.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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