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PRCP Antibody (N-term)

Catalog # Availability Size / Price Inquiry
APR03813G 100 μl / $495

PRCP Antibody (N-term)

Brand

Leading Biology

Catalog Number

APR03813G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PRCP Antibody (N-term).

Molecular Weight

55800 Da

Cellular Localization

Antigen Cellular Localization: Lysosome.

Host

Rabbit

Species Reactivity

Human

Immunogen

114-143 aa

Target

This PRCP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 114-143 amino acids from the N-terminal region of human PRCP.

Isotype

Rabbit Ig

Symbol

PCP

GeneID

UniProt ID

Function

Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.

Summary

The protein encoded by this gene is a lysosomalprolylcarboxypeptidase, which cleaves C-terminal amino acids linkedto proline in peptides such as angiotension II, III anddes-Arg9-bradykinin. The cleavage occurs at acidic pH, but theenzyme activity is retained with some substrates at neutral pH.This enzyme has been shown to be an activator of the cellmatrix-associated prekallikrein. The importance of angiotension II,one of the substrates of this enzyme, in regulating blood pressureand electrolyte balance suggests that this gene may be related toessential hypertension. Alternatively spliced transcript variantsencoding distinct isoforms have been observed. [provided byRefSeq].

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, E

Dilution

WB~~1:1000 IHC-P~~1:10~50

Images

PRCP Antibody (N-term) (Cat. APR03813G) western blot analysis in MDA-MB231,Hela cell line lysates (35ug/lane).This demonstrates the PRCP antibody detected the PRCP protein (arrow).

PRCP Antibody (N-term) (Cat. APR03813G)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PRCP Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Specification

Quantity

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