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CD320 Antibody (C-term)

Catalog # Availability Size / Price Inquiry
APR03779G 100 μl / $495

CD320 Antibody (C-term)

Brand

Leading Biology

Catalog Number

APR03779G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CD320 Antibody (C-term).

Molecular Weight

28991 Da

Cellular Localization

Antigen Cellular Localization: Membrane; Single-pass type I membrane protein

Host

Rabbit

Species Reactivity

Human

Immunogen

153-182 aa

Target

This CD320 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 153-182 amino acids from the C-terminal region of human CD320.

Isotype

Rabbit Ig

Symbol

8D6A

GeneID

UniProt ID

Function

Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10. Receptor for the cellular uptake of transcobalamin bound cobalamin.

Summary

The CD320 antigen gene encodes the transcobalamin receptor(TCBLR). Cellular uptake of cobalamin (vitamin B12) is mediated byreceptors expressed on the cell surface. Transcobalamin II (TCN2;MIM 613441), a plasma protein secreted by endothelial cells, bindsthe cobalamin absorbed in the distal ileum and carries 10 to 30% oftotal circulating cobalamin. CD320 encodes a transcobalaminreceptor that binds TCN2-cobalamin at the plasma membrane andinternalizes the complex by endocytosis (Quadros et al., 2009[PubMed 18779389]).

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, E

Dilution

WB~~1:1000

Images

CD320 Antibody (C-term) (Cat. APR03779G) western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the CD320 antibody detected the CD320 protein (arrow).

Specification

Quantity

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