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Parp9 Antibody (C-term)

Catalog # Availability Size / Price Inquiry
APR03594G 100 μl / $495

Parp9 Antibody (C-term)

Brand

Leading Biology

Catalog Number

APR03594G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Parp9 Antibody (C-term).

Molecular Weight

96659 Da

Cellular Localization

Antigen Cellular Localization: Cytoplasm, cytosol. Nucleus. Note=Shuttles between the nucleus and the cytosol Export to the cytosol depends on the interaction with DTX3L (By similarity). Localizes at sites of DNA damage in a PARP1-dependent manner (By similarity).

Host

Rabbit

Species Reactivity

Mouse

Immunogen

599-629 aa

Target

This Parp9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 599-629 amino acids from the C-terminal region of human Parp9.

Isotype

Rabbit Ig

Symbol

Bal

GeneID

UniProt ID

Function

In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes (By similarity).

Summary

PARP9 is a novel risk related gene that is expressed at higher levels in fatal high risk diffuse large B cell lymphomas.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, E

Dilution

WB~~1:1000 IHC-P~~1:50~100

Images

All lanes : Anti-Parp9 Antibody (C-term) at 1:1000 dilution Lane 1: mouse lung lysate Lane 2: mouse thymus lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 97 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

Parp9 Antibody (C-term) (Cat. APR03594G)immunohistochemistry analysis in formalin fixed and paraffin embedded human lymphoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Parp9 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Specification

Quantity

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