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JMJD5 Antibody (N-term)

Catalog # Availability Size / Price Inquiry
APR03509G 100 μl / $495

JMJD5 Antibody (N-term)

Brand

Leading Biology

Catalog Number

APR03509G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality JMJD5 Antibody (N-term).

Molecular Weight

47270 Da

Cellular Localization

Antigen Cellular Localization: Nucleus.

Host

Rabbit

Species Reactivity

Human

Immunogen

36-63 aa

Target

This JMJD5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-63 amino acids from the N-terminal region of human JMJD5.

Isotype

Rabbit Ig

Symbol

JMJD5

GeneID

UniProt ID

Function

Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.

Summary

This gene likely encodes a histone lysine demethylase.Studies of a similar protein in mouse indicate a potential role forthis protein as a tumor suppressor. Alternatively splicedtranscript variants have been described.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, E

Dilution

WB~~1:1000

Images

All lanes : Anti-JMJD5 Antibody (N-term) at 1:1000 dilution Lane 1: A549 whole cell lysate Lane 2: Hela whole cell lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 47 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

Western blot analysis of JMJD5 (arrow) using rabbit polyclonal JMJD5 Antibody (N-term) (Cat. APR03509G). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the JMJD5 gene.

Specification

Quantity

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