> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > CDKN2C Antibody (C-term)Brand |
Leading Biology | Catalog Number |
APR03501G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CDKN2C Antibody (C-term).
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Molecular Weight |
18127 Da
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Host |
Rabbit
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Species Reactivity |
Human, Mouse
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Immunogen |
113-139 aa
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Target |
This CDKN2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 113-139 amino acids from the C-terminal region of human CDKN2C.
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Isotype |
Rabbit Ig
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Symbol |
CDKN6
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GeneID |
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UniProt ID |
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Function |
Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
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Summary |
The protein encoded by this gene is a member of the INK4family of cyclin-dependent kinase inhibitors. This protein has beenshown to interact with CDK4 or CDK6, and prevent the activation ofthe CDK kinases, thus function as a cell growth regulator thatcontrols cell cycle G1 progression. Ectopic expression of this genewas shown to suppress the growth of human cells in a manner thatappears to correlate with the presence of a wild-type RB1 function.Studies in the knockout mice suggested the roles of this gene inregulating spermatogenesis, as well as in suppressingtumorigenesis. Two alternatively spliced transcript variants ofthis gene, which encode an identical protein, have been reported.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, E
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Dilution |
WB~~1:1000
IHC-P~~1:50~100
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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