> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > IL12_2 Antibody (C-term)Brand |
Leading Biology | Catalog Number |
APR03464G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality IL12_2 Antibody (C-term).
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Molecular Weight |
97135 Da
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Cellular Localization |
Antigen Cellular Localization:
Membrane; Single-pass type I membrane protein
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
756-783 aa
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Target |
This IL12_2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 756-783 amino acids from the C-terminal region of human IL12_2.
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Isotype |
Rabbit Ig
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GeneID |
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UniProt ID |
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Function |
Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.
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Summary |
The protein encoded by this gene is a type I transmembraneprotein identified as a subunit of the interleukin 12 receptorcomplex. The coexpression of this and IL12RB1 proteins was shown tolead to the formation of high-affinity IL12 binding sites andreconstitution of IL12 dependent signaling. The expression of thisgene is up-regulated by interferon gamma in Th1 cells, and plays arole in Th1 cell differentiation. The up-regulation of this gene isfound to be associated with a number of infectious diseases, suchas Crohn's disease and leprosy, which is thought to contribute tothe inflammatory response and host defense.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, FC, E
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Dilution |
WB~~1:1000
IHC-P~~1:10~50
FC~~1:10~50
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Images |
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Specification |
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Quantity |
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| 5 | Leading Biology | APR04349G | HECTD2 Antibody (N-term) | 100 μl | Polyclonal Antibodies |
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| 6 | Leading Biology | APR03502G | IGHG1 Antibody (Center) | 100 μl | Polyclonal Antibodies |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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