> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > SPARC Antibody(C-term) Antibody(Ascites)Brand |
Leading Biology | Catalog Number |
AMM02446G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality SPARC Antibody(C-term) Antibody(Ascites).
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Molecular Weight |
34632 Da
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Cellular Localization |
Antigen Cellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane. Note=In or around the basement membrane
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Host |
Mouse
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Species Reactivity |
Human
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Immunogen |
224-251 aa
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Target |
This SPARC antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 224-251 amino acids from the C-terminal region of human SPARC.
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Clone |
664CT7.3.1
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Isotype |
IgG1
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Symbol |
ON
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GeneID |
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UniProt ID |
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Function |
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
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Summary |
Secreted protein acidic and rich incysteine/osteonectin/BM40, or SPARC, is a matrix-associated proteinthat elicits changes in cell shape, inhibits cell-cycleprogression, and influences the synthesis of extracellular matrix(ECM) (Bradshaw et al., 2003 [PubMed 12721366]).
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:100~800
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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