> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > RET Antibody (Ascites)Brand |
Leading Biology | Catalog Number |
AMM02344G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality RET Antibody (Ascites).
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Molecular Weight |
124319 Da
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Cellular Localization |
Antigen Cellular Localization:
Cell membrane; Single-pass type I membrane protein Endosome membrane; Single-pass type I membrane protein
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Host |
Mouse
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Species Reactivity |
Human
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Target |
This RET Monoclonal antibody was raised using purified His-tagged recombinant human RET.
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Clone |
188CT11.2.3
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Isotype |
IgM,K
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Symbol |
CDHF12, CDHR16, PTC, RET51
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GeneID |
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UniProt ID |
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Function |
Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut- associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration.
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Summary |
This gene, a member of the cadherin superfamily, encodesone of the receptor tyrosine kinases, which are cell-surfacemolecules that transduce signals for cell growth anddifferentiation. This gene plays a crucial role in neural crestdevelopment, and it can undergo oncogenic activation in vivo and invitro by cytogenetic rearrangement. Mutations in this gene areassociated with the disorders multiple endocrine neoplasia, typeIIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease,and medullary thyroid carcinoma. Two transcript variants encodingdifferent isoforms have been found for this gene. Additionaltranscript variants have been described but their biologicalvalidity has not been confirmed.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, IF, E
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Dilution |
WB~~1:500~16000
IHC-P~~1:50~100
IF~~1:10~50
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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