We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality M1 Muscarinic Receptor (443-458) antibody.

51421 Da

Rabbit

Human, Mouse, Rat

Peptide (C)RKIPKRPGSVHRTPSR, corresponding to amino acid residues 443-458 of human M1 Muscarinic Receptor (Accession P11229). Intracellular, C-terminus.

The action of the neurotransmitter acetylcholine is mediated through two types of receptors, the ionotrophic nicotinic receptors and the metabotrophic muscarinic receptors. The muscarinic receptors belong to the superfamily of 7-TM G-protein coupled receptors. Five subtypes of muscarinic receptors have been cloned and named m1-m51,2.The muscarinic receptors are widely distributed throughout the body, but are predominantly expressed within the parasympathetic nervous system and exert both excitatory and inhibitory control over central and peripheral tissues1,2.Muscarinic receptors participate in a number of physiological functions such as regulation of heart rate, muscle contraction, cognition, sensory processing and motor control1. They also participate in learning and memory processing3,4. The m1 receptors are the most abundant muscarinic subtype in the cortex and striatum. m1 receptors are also localized in the myenteric plexus where they function as autoreceptors to enhance the release of Ach from the nerves5,6.The m1, m3 and m5 receptors, which are coupled to Gq/11 proteins, can protect cells from apoptosis induced by DNA damage. The signaling mechanism that mediates this anti-apoptotic response is still poorly understood. However, it was recently reported that a poly-basic motif in the C-terminus tail of the m1, m3 and m5 receptors is an essential element for the anti-apoptotic response of those receptors7.Abgent is pleased to offer a highly specific antibody directed against an epitope human m1 receptor. Anti-M1 Muscarinic Receptor (443-458) antibody (#AG1215) can be used in western blot analysis and immunohistochemistry applications. It has been designed to recognize m1 from mouse, ratand human samples.

Affinity purified antibody, Liquid

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

WB

WB~~1:200-1:2000 IHC~~1:100

Muscarinic acetylcholine receptor M1, CHRM1

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