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TGFBR2 Antibody (N-term)

APR03625G Product Datasheet Protocol

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APR03625G		100 μl / $495

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Leading Biology Inc.

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TGFBR2 Antibody (N-term)

Brand	Leading Biology	Catalog Number	APR03625G
Product Type	Polyclonal Antibodies	Field of Research
Product Overview	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TGFBR2 Antibody (N-term).
Molecular Weight	64568 Da
Cellular Localization	Antigen Cellular Localization: Cell membrane; Single-pass type I membrane protein
Host	Rabbit
Species Reactivity	Human, Mouse
Immunogen	13-40 aa
Target	This TGFBR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-40 amino acids from the N-terminal region of human TGFBR2.
Isotype	Rabbit Ig
GeneID	7048
UniProt ID	P37173
Function	Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non- canonical, SMAD-independent TGF-beta signaling pathways.
Summary	This gene encodes a member of the Ser/Thr protein kinasefamily and the TGFB receptor subfamily. The encoded protein is atransmembrane protein that has a protein kinase domain, forms aheterodimeric complex with another receptor protein, and bindsTGF-beta. This receptor/ligand complex phosphorylates proteins,which then enter the nucleus and regulate the transcription of asubset of genes related to cell proliferation. Mutations in thisgene have been associated with Marfan Syndrome, Loeys-Deitz AorticAneurysm Syndrome, and the development of various types of tumors.Alternatively spliced transcript variants encoding differentisoforms have been characterized.
Storage & Stability	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Applications	WB, IHC-P, IF, E
Dilution	IHC-P~~1:10~50 WB~~1:1000 IF~~1:10~50
Images	APR03625G staining TGFBR2 in human brain sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody (1/25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody. APR03625G staining TGFBR2 in human brain sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody (1/25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody. All lanes : Anti-TGFBR2 Antibody (N-term) at 1:2000 dilution Lane 1: human testis lysate Lane 2: mouse lung lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 67 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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