We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Caspr2 antibody.

148167 Da

Rabbit

Mouse, Rat

Peptide (C)DPNFTETIDESKKEWLI, corresponding to amino acid residues 1315-1331 of human Caspr2 (Accession Q9UHC6). Intracellular, C-terminus.

Contactin-associated protein 2 (Caspr2) is a member of the neurexin superfamily, a group of transmembrane proteins that mediate cell–cell interactions in the nervous system1,2.Neurexins are adhesion molecules expressed mainly at presynaptic locations that form trans-synaptic cell – cell adhesion complexes via binding to their postsynaptic partners the neuroligins2.Caspr2, like other neurexin proteins, is a type I membrane protein that contains epidermal growth factor repeats, laminin G domains, an F5/8 type C domain, and fibrinogen-like domains in its extracellular domain1,2.Caspr2 is localized at the juxtaparanodes of myelinated axons, a specialized region that mediates interactions between neurons and glia during nervous system development1.The juxtaparanodal region is highly enriched with heteromultimers of the K+ channels Kv1.1, Kv1.2, and their cytoplasmic Kvß2 subunit, which may help in axon conduction stabilization and the maintenance of the internodal resting potential1. Caspr2 is essential for the targeted localization of these channels in the juxtaparanodal regions. Indeed, targeted disruption of Caspr2 resulted in a marked reduction in the accumulation of K+ channels at the juxtaparanodes in both peripheral and central nervous system axons3.Moreover, mutations in the Caspr2 gene have been implicated in multiple neurodevelopmental disorders, including Tourette syndrome, schizophrenia, epilepsy, autism, attention-deficit hyperactivity disorder and mental retardation4-6.Abgent is pleased to offer a highly specific antibody directed against an epitope located at the intracellular C-terminal domain of human Caspr2. Anti-Caspr2 antibody (#AG1050) can be used in Western blot applications, and was designed to recognize Caspr2 from rat, mouse and human samples.

Affinity purified antibody, Liquid

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

WB

WB~~1:200-1:2000 IHC~~1:200

Contactin-associated protein-like 2, Cell recognition molecule Caspr2, CNTNAP2, CASPR2 {ECO:0000303|PubMed:10624965}, KIAA0868

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