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Aquaporin 1 Antibody

Catalog # Availability Size / Price Inquiry
APG01971G 50 μl / $695

Aquaporin 1 Antibody

Brand

Leading Biology

Catalog Number

APG01971G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Aquaporin 1 antibody.

Molecular Weight

28526 Da

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Target

Peptide (C)KVWTSGQVEEYDLDADDIN corresponding to amino acid residues 242-260 of human AQP1 (accession number P29972). Intracellular, C-terminus.

GeneID

UniProt ID

Summary

Aquaporin 1 (AQP-1) belongs to a family of membrane proteins that allow passage of water and certain other solutes through biological membranes. The family is composed of 13 members (AQP-0 to AQP-12).The aquaporins can be divided into two functional groups based on their permability characteristics: the aquaporins that are only permeated by water and the aquaglyceroporins that are permeated by water and other small solutes such as glycerol. AQP-1 together with AQP-2, AQP-4 and AQP-5 belongs to the first group.1Little is known about the function of the two newest members, AQP-11 and AQP-12.The proteins present a conserved structure of six transmembrane domains with intracellular N- and C-termini. The functional channel is a tetramer but each subunit has a separate pore and therefore the functional channel unit, contains four pores.1AQP-1 is widely expressed in several organs with prominent expression found in kidney, lung, red blood cells intestine and brain. Studies with mice lacking AQP-1 show that the channel has a critical role in urine concentration.2In addition, AQP-1 expression in tumor cells was shown to contribute to enhanced tumor spread and metastatic potential.3

Form

Affinity purified antibody, Liquid

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB

Dilution

WB~~1:200-1:2000 IHC~~1:100

Synonyms

Aquaporin-1, AQP-1, Aquaporin-CHIP, Urine water channel, Water channel protein for red blood cells and kidney proximal tubule, AQP1, CHIP28

Images

Western blot analysis of rat kidney membranes: 1. Anti-Aquaporin 1 antibody (APG01971G), (1:400). 2. Anti-Aquaporin 1 antibody, preincubated with the control peptide antigen .

Expression of Aquaporin 1 in rat kidney Immunohistochemical staining of paraffin-embedded rat kidney sections using Anti-Aquaporin 1 antibody ( APG01971G), (1:100). AQP1 staining (brown) is present in both distal (DT) and proximal (PT) convoluted tubules in the renal cortex. Note that a weak staining is also present in collecting ducts (CD) while glomeruli (Gl) are negative. Hematoxilin is used as the counterstain.

Specification

Quantity

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