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DDC Antibody

Catalog # Availability Size / Price Inquiry
APR07525G 0.1 mg / $695

DDC Antibody

Brand

Leading Biology

Catalog Number

APR07525G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality DDC antibody .

Molecular Weight

Predicted: 53 kDa Observed: 50 kDa

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Target

DDC; DDC antibody is human, mouse and rat reactive.

Isotype

IgG

Symbol

AADC

GeneID

UniProt ID

Function

Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.

Summary

DOPA decarboxylase (DDC) belongs to the group II decarboxylase family of proteins (1). It is an important protein in the catecholamine biosynthesis pathway. DDC catalyzes the second reaction in the biosynthesis of catecholamines, trace amines and serotonin (1,2). It can form a homodimer and is expressed in the central nervous system (2). DDC can be used as markers for dopaminergic, noradrenergic and serotonergic neurons in a variety of applications including depression, schizophrenia, Parkinson's disease, neuroendocrine tumors and drug abuse (3,4). Defects in DDC gene may cause the autosomal recessive disorder AADC deficiency (4).

Form

Liquid

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, IF, E

Images

Western blot analysis of DDC in human lung tissue lysate with DDC antibody at 1 μg/ml.

Immunohistochemistry of DDC in human lung tissue with DDC antibody at 2.5 μg/mL.

Immunofluorescence of DDC in human lung tissue with DDC antibody at 20 μg/mL.

Specification

Quantity

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