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DISP1 Antibody

Catalog # Availability Size / Price Inquiry
APR11735G 0.1 mg / $695

DISP1 Antibody

Brand

Leading Biology

Catalog Number

APR11735G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality DISP1 antibody.

Molecular Weight

170934 Da

Cellular Localization

Antigen Cellular Localization: Membrane; Multi-pass membrane protein

Host

Rabbit

Species Reactivity

Human, Mouse

Target

DISP1; At least two isoforms of DISP1 are known to exist; this antibody will detect both isoforms. DISP1 antibody is predicted to not cross-react with EMX1.

Isotype

IgG

Symbol

DISPA

GeneID

UniProt ID

Function

Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity).

Summary

DISP1 Antibody: DISP1 is the mammalian homolog of the Drosophila Dispatched segment-polarity gene and a key regulator of the Hedgehog (Hh) signaling pathway during embryonic development. DISP1 is required to move Shh from site of synthesis during embryogenesis; mutations in the gene result in lethality at mid-gestation and prevents specification of ventral cell types in the neural tube. Recent results have shown that DISP1 mediates the basolateral secretion of Shh and regulates growth of mammalian long bones through the control of Ihh.

Form

Liquid

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, IF, E

Images

Western blot analysis of DISP1 in 3T3 cell lysate with DISP1 antibody at 1 μg/mL.

Immunohistochemistry of DISP1 in human kidney tissue with DISP1 antibody at 2.5 μg/mL.

Immunofluorescence of DISP1 in human kidney tissue with DISP1 antibody at 20 μg/mL.

Specification

Quantity

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