> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > EPO AntibodyBrand |
Leading Biology | Catalog Number |
AMM04425G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality EPO antibody.
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Molecular Weight |
21307 Da
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Cellular Localization |
Antigen Cellular Localization:
Secreted.
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Host |
Rabbit
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Species Reactivity |
Human
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Target |
EPO
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Isotype |
Rabbit Ig
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GeneID |
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UniProt ID |
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Function |
Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.
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Summary |
Human erythropoietin (EPO) is an acidic glycoprotein. It is mainly produced by the kidney. As the primary regulator of the production of red cells, its major functions are to promote erythroid progenitor cells differentiation and to start the synthesis of hemoglobin. EPO acts by binding to a specific erythropoietin receptor (EPOR) on target cells; the red cell precursors in the bone marrow, and induces their transformation into mature erythrocytes. The EPO sensitivity increases with differentiation of immature progenitor cells. EPO may act as a neuron protector against glutamate toxicity. Its neuroprotective activity comes into effect by neutralizing the toxicity of free radicals. EPO is produced in brain after oxidative stress. EPO is upregulated by hypoxia and prevents apoptosis of erythroid progenitors in bone.
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Form |
1 mg/ml in PBS with 0.007% (W/V) sodium azide |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB
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Synonyms |
Erythropoietin-Alpha, EPO-a, EPO-alpha, Epoetin, EP, MGC138142
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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