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SREBP2 Antibody

APR10243G Product Datasheet Protocol

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APR10243G		100 μl / $495

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Leading Biology Inc.

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SREBP2 Antibody

Brand	Leading Biology	Catalog Number	APR10243G
Product Type	Polyclonal Antibodies	Field of Research
Product Overview	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SREBP2 antibody.
Molecular Weight	123688 Da
Cellular Localization	Antigen Cellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols
Host	Rabbit
Species Reactivity	Human
Target	SREBP2
Isotype	Rabbit Ig
Symbol	BHLHD2, SREBP2
GeneID	6721
UniProt ID	Q12772
Function	Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.
Summary	SREBP2 regulates cholesterol synthesis by activating the transcription of genes for HMG-CoA reductase and other enzymes of the cholesterol synthetic pathway.2 SREBP2 is ubiquitously detected in various tissues. Under basal conditions SREBP is bound to ER membranes as a glycosylated precursor protein. Upon cholesterol depletion, the protein is cleaved to its active forms (about 50-68 kDa) and translocated into the nucleus to stimulate transcription of genes involved in the uptake and synthesis of cholesterol.
Form	In PBS with 0.09% (W/V) sodium azide.
Storage & Stability	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Applications	WB
Synonyms	Sterol regulatory element-binding protein 2, SREBF2, Class D basic helix-loop-helix protein 2, bHLHd2, Sterol regulatory element-binding transcription factor 2, Processed sterol regulatory element-binding protein 2, SREBF2, BHLHD2, SREBP2
Images	Flurescent image of U251 cell stained with SREBP2 Antibody. Cells were fixed with 4% PFA(20min), permeabilized with Triton X-100 (0.1%, 10min), then incubated with SREBP2 primary antibody (1:25, 1h at 37℃). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50min at 37℃). Cytoplasmic actin was counterstained with Alexa Fluor 555 (red) conjugated Phalloidin (7units/ml, 1h at 37℃). SREBP2 immunoreactivity is localized to Nucleus and Nucleolus siginficantly. SREBF2 Antibody western blot analysis in HepG2 cell line lysates (35ug/lane). This demonstrates the SREBP2 antibody detected the SREBP2 protein. SREBP2 antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human skin carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SREBP2 antibody for immuohistochemistry. Clinical relevance has not been evaluated.
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